Events & Congress

CRRT Conference Industry Lunch Symposium
Sponsored by Spectral

Endotoxin: Detecting and Treating an Old Foe with New Weapons.
Dr. Ashita Tolwani: What is endotoxin and why is it important?
Dr. John Kellum:  Treating an old foe with new weapons. 

Friday March 31, 2023 @ 12:30 – 2:00 PM

38th Vicenza Course on AKI & CRRT (Virtual)
Watch the course replays
November 2-6, 2020
European Society of Intensive Care Medicine (ESICM) Symposium: Precision Therapy in Unresponsive Endotoxic Shock. 
Chairpersons: P. Honoré (Brussels), C. Ronco (Vicenza)
Monday September 30th, 2019: 18:15-19:15
ISICEM Lunch Symposium: Polymyxin B Hemoperfusion as Complementary Therapy in Septic Shock: Rationale and Evidence.
Ricard Ferrer & Claudio Ronco
Tuesday March 19th, 2019: 12:30-13:30
Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial
D. J. Klein, D. Foster, P. M. Walker, S. M. Bagshaw, H. Mekonnen, M. Antonelli
Intensive Care Medicine (23 November 2018)
Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level
R. Phillip Dellinger, MD, MSc; Sean M. Bagshaw, MD, MS; Massimo Antonelli, MD; et al
JAMA. 2018;320(14):1455-1463
Novel Insights into the Direct Removal of Endotoxin by Polymyxin B Hemoperfusion
Romaschin A.D. · Obiezu-Forster C.V. · Shoji H. · Klein D.J.
Blood Purification Vol. 44, No. 3, 2017
Replay the Live Broadcast:
35th annual Vicenza Course on AKI and CRRT:
Critical Care Nephrology Cases Presentation – Results of the EUPHRATES Trial
Presented by Professor Massimo Antonelli, June 2017
Intervening in Sepsis: Can Nurses Do More?
Updated guidelines may help nurses identify sepsis quicker and treat it more efficiently

Debra M. Foster
Healthcare Network for Nurses January 2017
Role of Technology for the Management of AKI in Critically Ill Patients: From Adoptive Technology to Precision Continuous Renal Replacement Therapy
Cerdá J., Baldwin I., Honore P.M., Villa G., Kellum J.A., Ronco C.
Blood Purification Vol. 42, No. 3, September 2016
Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry
Salvatore Lucio Cutuli, Antonio Artigas, Roberto Fumagalli, Gianpaola Monti, Vito Marco Ranieri, Claudio Ronco, Massimo Antonelli.
Annals of Intensive Care, August 2016
Endotoxin Removal: Bringing the Mission to North America 
Foster D., Klein D.J,. Guadagni G.,Walker P.M.
Blood Purification, Vol. 37, Suppl. 1, January 2014 
Systemic endotoxin activity correlates with clot formation: an observational study in patients with early systemic inflammation and sepsis
Alexander Koch, Michael Isaäc Meesters, Bertram Scheller, Christa Boer and Kai Zacharowski
Critical Care, 17:R198, September 2013
Immunomodulation in Sepsis: The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge
Elisabeth Esteban, Ricard Ferrer, Laia Alsina, and Antonio Artigas
Mediators of Inflammation Volume 2013 (2013), Article ID 507539, September 2013
Blood Purification and Mortality in Sepsis: A Meta-analysis of Randomized Trials
Zhou, Feihu MD, PhD; Peng, Zhiyong MD, PhD; Murugan, Raghavan MD, MS, FRCP; Kellum, John A. MD, MCCM
Crit Care Med. September 2013 – Volume 41 – Issue 9 – p 2209-2220
Severity and prognostic assessment of the endotoxin activity assay in biliary tract infection.
Sato M, Matsuyama R, Kadokura T, Mori R, Kumamoto T, Nojiri K, Taniguchi K, Takeda K, Kubota K, Tanaka K, Endo I.
Journal of Hepato-Biliary-Pancreatic Sciences, 2013 June
Endotoxin activity levels as a prediction tool for risk of deterioration in patients with sepsis not admitted to the intensive care unit: A pilot observational study
Emanuela Biagioni, MD , Claudia Venturelli, BS , David J. Klein, MD , Marta Buoncristiano, MS , Fabio Rumpianesi, MD , Stefano Busani, MD , Laura Rinaldi, MD , Abele Donati, MD , Massimo Girardis
Journal of Critical Care, April 2013, j.jcrc.2013.02.005
Prognostic value of endotoxin activity assay in patients with severe sepsis after cardiac surgery.
Michail Yaroustovsky, Marina Plyushch, Dmitry Popov, Natalia Samsonova, Marina Abramyan, Zakhar Popok and Nickolay Krotenko
Journal of Inflammation, March 2013, 10:8
Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients.
D. Grimaldi , E. Guivarch , N. Neveux , J. Fichet , F. Pène , J.-S. Marx , J.-D. Chiche , L. Cynober , J.-P. Mira , A. Cariou
Resuscitation Volume 84, Issue 1 , Pages 60-65, January 2013
Bench-to-bedside review: Clinical experience with the endotoxin activity assay.
Alexander D Romaschin, David J Klein and John C Marshall
Critical Care 2012, 16:248, December 2012
Increased endotoxin activity is associated with clinical deterioration in moderate-severity emergency department sepsis patients: a pilot study
R Arnold, C Schorr, S Trzeciak and RP Dellinger
Critical Care 2012, Volume 16. Supp. 3, Sepsis 2012, November 2012
Safety of Polymyxin-B–based Hemoperfusion in Kidney and Liver Transplant Recipients
Yukihiro G. Novelli, V. Morabito, G. Ferretti, L. Poli, S. Novelli, F. Ruberto, F. Pugliese, G. Mennini, M. Rossi, PB. Berloco
Transplantation Proceedings, Sept 2012
Time to Initiation of Treatment with Polymyxin B Cartridge Hemoperfusion in Septic Shock Patients
Yukihiro Takeyama N. Noguchi H. Hirakawa A. Kano H. Morino K. Obata T. Sakamoto T. Tamai F. Ishikura H.f· Kase Y. Kobayashi M. Naka T. Takahashi Y.
Blood Purification, Vol. 33, No. 4, June 2012 
Impact of endotoxin measured by an endotoxin activity assay during liver transplantation
Yukihiro Sanada, MD , Koichi Mizuta, MD, PhD , Taizen Urahashi, MD, PhD , Yoshiyuki Ihara, MD, PhD , Taiichi Wakiya, MD, Noriki Okada, MD , Naoya Yamada, MD , Kentaro Ushijima, PhD , Shinya Otomo , Koichi Sakamoto, PhD , Yoshikazu Yasuda, MD, PhD , Hideo Kawarasaki, MD, PhD
Journal of Surgical Research, May 2012
Combining intermediate levels of the Endotoxin Activity Assay (EAA) with other biomarkers in the assessment of patients with sepsis: results of an observational study
Arino Yaguchi, Junji Yuzawa, David J Klein, Munekasu Takeda and Tomoyuki Harada
Critical Care 2012, 16:R88
Clinical usefulness of measuring endotoxin activity on ICU admission
A Murai, H Ishikura, T Nishida, Y Irie, T Kamitani, R Yuge, T Kitamura and T Umemura
Critical Care 2012, 16 (Suppl 1):P34